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Updated: May 5, 2026

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
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含化合物的缓解脊髓损伤机制分析基于网络药理学和分子对接技术

Wen Han1, Ling Xie2,3, Chaochao Ding1

  • 1Department of Pharmacy, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China.

Molecular neurobiology
|July 2, 2024
PubMed
概括

化合物34#是一种含有的分子,在治疗脊髓损伤 (SCI) 中表现有前途. 网络药理学和实验证实了它的抗SCI作用,并确定了未来SCI治疗的关键标.

关键词:
分子对接技术分子对接技术.网络药理学 网络药理学脊髓损伤导致的脊髓损伤

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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