肌缩侧面硬化症患者的情绪意识
Veronica Faltracco1, Barbara Poletti2,3, Edoardo Nicolò Aiello2
1Third Neurology Unit and Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Luigi Celoria 11, 20133, Milan, Italy.
概括
亚历克西西米亚,处理情绪的困难,在肌缩性侧面硬化症 (ALS) 患者中进行了研究. 研究结果表明,它不是ALS中特定的前神经综合征,而是可能反映出对疾病的心理反应.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 神经心理学 神经心理学
背景情况:
- 情绪处理缺陷的alexithymia越来越多地被认为是前光谱障碍的潜在特征.
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,影响运动神经元,并可能导致认知和行为变化.
- 在ALS中,alexithymia和前性综合征之间的关系需要进一步调查,以澄清其诊断和预后意义.
研究的目的:
- 为了调查alexithymia的患病率和临床相关的非痴呆性肌缩侧面硬化症 (ALS) 患者队列.
- 确定亚历克西西米亚是否代表ALS频谱内的特定的前腔综合征.
- 探索ALS中alexithymic特征与各种神经心理,认知和行为特征之间的关联.
主要方法:
- 一组68名非痴呆性ALS患者的队列使用20项多伦多亚历克西西米亚量表 (TAS-20) 评估了亚历克西西米亚特征.
- 根据既定的分类标准,对患者的运动表型和前性综合征进行了评估.
- 斯皮尔曼的相关系数被用来分析TAS-20分数和运动功能概况,全球认知,社会认知 (情绪识别,同情) 和行为状态之间的关系.
主要成果:
- 在13%的ALS患者中发现了异常的alexithymia评分 (TAS-20),在运动或前性表型之间没有显著的变化.
- TAS-20得分显示了与执行功能,记忆,状态焦虑和抑郁症指标的显著关联.
- 亚历克西西米亚与社会认知表现和执行力或冷漠性无关; 疾病持续时间是唯一相关的运动功能特征.
结论:
- 潜在的临床相关性alexithymia影响少数ALS患者,其神经心理相关性与一般人群中的相关性相似.
- 这些发现表明,alexithymia不太可能是一个特定的前光谱特征,特征ALS.
- 在ALS中出现的alexithymia可能代表了对疾病的心理反应,而不是核心综合征的特征.
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