在接受血液透析的患者中,血清度与认知功能之间的关联
Kazuhiko Kato1,2, Akio Nakashima3, Shunichiro Shinagawa4
1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Clinical and experimental nephrology
|July 2, 2024
概括
较高的血清水平与血液透析患者更好的认知功能相关. 其他CKD-MBD标志物,如PTH和维生素D,与认知没有显著的关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 神经学 神经学
- 生物化学 生物化学
背景情况:
- 慢性病 - 矿物质和骨疾病 (CKD-MBD) 与认知障碍之间的联系尚不清楚.
- 在接受血液透析的患者中,CKD-MBD是常见的.
研究的目的:
- 研究CKD-MBD标志物与血液透析患者的认知功能之间的关联.
- 探索血清,PTH,25-OHD,FGF-23和α-klotho在认知健康中的作用.
主要方法:
- 对390名65岁或以上的血液透析患者进行横截面研究,这些患者没有被诊断为痴呆症.
- 使用蒙特利尔认知评估 (MoCA) 和迷你精神状态检查 (MMSE) 评估认知功能.
- 测量了血清中,完整的PTH,25-OHD,FGF-23和可溶性α-klotho的水平.
主要成果:
- 血清度较高的患者显示MoCA和MMSE得分明显更好.
- 未调整和调整的分析证实了高度与保持认知功能之间的积极关联.
- 在认知功能和完整的PTH,25-OHD,FGF-23或可溶性α-klotho之间没有发现显著的关联.
结论:
- 血清水平升高可能与血液透析患者的认知功能保持有关.
- 血清是影响这一群体认知健康的潜在因素.
- 研究的其他CKD-MBD标志物似乎与认知功能没有直接关联.
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