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针对非黑色素瘤皮肤癌的系统治疗:最新进展
Spencer Lessans1, Katie A O'Connell2, Jennifer Choe3
1Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Current oncology reports
|July 2, 2024
概括
包括免疫疗法在内的全身疗法正在彻底改变非黑色素瘤皮肤癌治疗. 这些进步为晚期皮肤癌,如状细胞癌,基底细胞癌和默克尔细胞癌提供了更好的生存率.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
背景情况:
- 非黑色素瘤性皮肤癌 (NMSC) 包括状细胞癌,基底细胞癌和默克尔细胞癌.
- 历史上,高级或转移性NMSC的治疗选择有限,预后不佳.
研究的目的:
- 对高级或转移性非黑色素瘤皮肤癌的已批准和新兴的全身疗法进行审查.
- 要突出最近在NMSC的处理景观的进步.
主要方法:
- 对局部晚期或转移性NMSC的全身疗法的文献综述.
- 分析临床试验数据和已批准的治疗方法.
主要成果:
- 免疫疗法在所有NMSC类型中都显示出显著的有效性,彻底改变了治疗结果.
- 刺抑制剂 (HHI) 是基底细胞癌 (BCC) 的第一线治疗药物,但有耐受性问题.
- 抗PD-1和抗PD-L1疗法正在研究在先进的NMSC中用于新辅助和辅助剂.
结论:
- 系统疗法,特别是免疫疗法,大大提高了晚期NMSC的存活率.
- 目前正在进行的研究继续扩大NMSC治疗的治疗武器库.
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