摄影诱导的非对称的形式西洛西碳插入到sp3C-H键中,由酸酸激活
Zi-Yi Xie1, Qiang-Qiang Li1, Yang Liu1
1Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, College of Chemistry & Chemical Engineering, Anhui University, Hefei, Anhui 230601, China.
Organic letters
|July 2, 2024
概括
这项研究引入了一种新型的enantioselective siloxycarbene插入反应,使用奇拉酸和蓝色LED光. 这种没有过渡金属的方法可以有效地创建具有高选择性的奇拉四等碳中心.
科学领域:
- 有机化学 有机化学
- 不对称的催化剂.
- 绿色化学 绿色化学
背景情况:
- 在有机合成中,开发用于C-H键功能化的不对称方法至关重要.
- 以前的方法通常依赖于过渡金属,限制了它们的范围和可持续性.
- 创造奇拉四等碳中心仍然是一个重要的合成挑战.
研究的目的:
- 开发一种新型的enantioselective形式的西洛西碳插入反应.
- 在没有过渡金属的条件下,在sp3 C-H键中实现不对称的插入.
- 建立一种绿色和高效的方法来合成奇拉四等碳中心.
主要方法:
- 利用酸作为一种有机催化剂.
- 采用蓝色发光二极管 (LED) 辐射来驱动反应.
- 研究了sp3 C-H 键中正规的西洛キシ碳插入.
主要成果:
- 在没有过渡金属的情况下实现了第一个不对称的西洛西碳二烯插入sp3 C-H键.
- 获得高达92%的良好的孤立产量.
- 证明了高的反抗选择性,达到高达99:1er (反抗分子比率).
结论:
- 开发的方法是高效的,温和的,并表现出良好的基材兼容性.
- 这种方法提供了一个绿色和有效的策略,用于构建合四等碳中心.
- 没有过渡金属的性质提高了合成的实用性和可持续性.
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