APIS:一个更新的父系分配软件,管理来自双胞胎父母诱导的三胞胎
Julien Roche1,2, Ronan Griot1,2,3, François Allal3
1SYSAAF (French Poultry and Aquaculture Breeders Technical Centre), 35042 Rennes, France.
G3 (Bethesda, Md.)
|July 2, 2024
概括
R包APIS的新更新使得水产养殖三种动物的DNA亲属性分配成为可能. 该软件有助于估计无菌三鱼的繁殖价值,这对于提高生产和质量至关重要.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 遗传学 遗传学 是一个
- 生物信息学是一种生物信息学.
背景情况:
- 无菌的三体动物在水产养殖中提供了生产优势,但不能繁殖.
- 准确的DNA亲属性分配对于估计三毛动物的繁殖价值至关重要.
- 现有的软件没有能力为三种类型的个体分配亲属.
研究的目的:
- 更新R包APIS用于三倍亲属关系赋值.
- 开发方法,以计算三倍体繁殖中独特的遗传贡献.
- 建立一个可靠的水产养殖遗传管理工具.
主要方法:
- 更新了APIS包,其中包含了三种类型的新排除和概率表.
- 占据了来自大和介质重组的双基贡献.
- 使用单核酸多态性 (SNP) 标记物,并根据标记物质量和数量评估分配功率.
主要成果:
- 96-192 SNP 足以实现彩虹鱼的高亲属性分配率.
- 赋值功率受到标记质量 (小等位基频率,调用率) 的影响.
- 概率方法对于有限的标志物是有效的;排除与更多的标志物相美,实现高灵敏度和特异性.
结论:
- 更新的APIS包提供了一个有效的解决方案,用于将三倍体分配给它们的双倍体父母.
- 该工具支持水产养殖中的基因改进计划,通过使繁殖价值估计成为可能.
- 这些发现为在亲属关系分配研究中选择标记物和数据质量提供了实际指导方针.
相关概念视频
Trihybrid Crosses
23.2K
Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal...
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal...
23.2K
Crossing Over
146.7K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
146.7K
Nondisjunction
75.5K
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
75.5K
Pedigree Analysis
84.2K
Overview
84.2K


