间歇性囊炎/膀疼痛综合征的症状自主功能障碍
Rory Ritts, Dylan Wolff1, Mary Namugosa
1From the Department of Urology, Wake Forest University School of Medicine.
Urogynecology (Philadelphia, Pa.)
|July 2, 2024
概括
自主神经系统功能障碍在间歇性囊炎/膀疼痛综合征 (IC/BPS) 中很常见. 较高的自主性症状严重程度与非膀中心的呈现相关,这表明IC/BPS患者的神经系统广泛参与.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 自主神经科学 自主神经科学
- 疼痛医学 医学 疼痛医学
背景情况:
- 间歇性囊炎/膀疼痛综合征 (IC/BPS) 是一种普遍存在的疾病,其病理生理不清楚,特别是在系统性症状方面.
- 自主神经系统 (ANS) 功能障碍在IC/BPS中的作用尚不清楚.
研究的目的:
- 调查自主症状严重程度与被诊断为IC/BPS的患者的临床特征之间的关联.
主要方法:
- 一项回顾性队列研究,涉及122名IC/BPS患者,他们完成了复合自主症状得分 (COMPASS-31).
- 收集的数据包括膀容量,汉纳病变状态,IC/BPS症状得分 (ICSI/ICPI,PUF) 和并发性非泌尿综合征.
- 患者被分为低 (第一四分位数COMPASS-31) 和高症状负载组进行比较.
主要成果:
- 具有较高自主症状得分 (≥20.36) 的患者患亨纳病变的可能性较低 (10.9%与26.7%相比).
- 较高的症状负载与膀容量增加 (823.10 vs 635.00 mL) 和较高的盆腔疼痛和急性/频率 (PUF) 评分 (23.80 vs 19.61) 相关联.
- 在自主症状严重程度较高的患者中观察到显著增加的非泌尿相关综合征 (5.65对2.60).
结论:
- 患有IC/BPS的患者表现出与自主神经系统功能障碍相关的广泛症状.
- 自主性症状严重程度的增加与IC/BPS中非膀中心的临床表现密切相关.
- 这些发现支持在非膀为中心的IC/BPS病例中存在全身神经系统功能障碍.
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