相关实验视频

Updated: Jun 22, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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工程微型G蛋白阻断了相关GPCRs的内化,并破坏了下游的细胞内信号传递

Yusman Manchanda1, Liliane ElEid1, Affiong I Oqua1

  • 1Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, UK.

Science signaling
|July 2, 2024
PubMed
概括

过度表达迷你G蛋白破坏了G蛋白结合受体 (GPCR) 的贩运和信号传递. 另一种纳米体测定方法可以避免这些影响,提供一种更可靠的方法来研究GPCRs.

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