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Updated: Jun 22, 2025

Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays
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在白血病前的细胞中,JAM-C的遗传删除将在AML中重新连接白血病干细胞基因表达程序

Julien M P Grenier1,2, Céline Testut1, Matthieu Bal1,3

  • 1Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Equipe Labellisée Ligue 2020, Marseille, France.

Blood advances
|July 2, 2024
PubMed
概括

白血病干细胞 (LSC) 在骨髓中定,受结合粘附分子-C (JAM-C) 的影响,影响急性髓性白血病 (AML) 的预后. 一个新的基因特征改善了LSC-17得分,以更好地预测患者分层和生存率.

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