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精神分裂症和双极性障碍中神经网膜变化:一个更新的元分析

Nora Sheehan^1,2, Deepthi Bannai^1,2, Steven M Silverstein^3,4,5

¹Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Schizophrenia bulletin

|July 2, 2024

概括

光学连贯断层扫描揭示了精神分裂症和双相情感障碍患者的视网膜结构异常. 周周毛囊和黄斑区域都在变薄,这表明这些精神疾病中存在共同和独特的变化.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
精神病学是一个精神病学.

背景情况:

精神分裂症 (SZ) 和双相情感障碍 (BD) 呈现出显著的症状,认知和神经解剖学变化.
光学连贯断层扫描 (OCT) 已成为研究SZ和BD视网膜变化的工具.
需要进一步评估SZ和BD中共享和独特的视网膜变化.

研究的目的:

对SZ和BD视网膜变化的近期OCT研究进行元分析.
与健康对照组 (HC) 相比,在SZ和BD患者中确定独特和共享的视网膜结构异常.
为了探索年龄,疾病持续时间和吸烟等因素的潜在缓解效应.

主要方法:

在PubMed和Google Scholar的系统文献搜索中,寻找相关的OCT研究.
包括39项研究,分析了来自3145名患者眼睛 (1956 SZ, 1189 BD) 和3135名HC眼睛的数据.
使用固定和随机效应模型进行的元分析,并进行出版偏差校正 (修剪和填充分析).

主要成果:

精神分裂症患者表现出周状视网膜神经纤维层 (pRNFL) 和黄斑视网膜 (m-Retina) 和其他子区域的稀薄.
双极性障碍患者的pRNFL,pGCC和黄斑视网膜变薄,但视网膜总厚度没有变化.
两组都没有显示出足,mRNFL,mGCL,mGCC,mINL,mOPL,mONL或胸膜厚度的显著变化.

结论:

这一元分析证实,与HC相比,SZ或BD的个体在周围毛囊和黄斑区域都存在视网膜结构异常.
确定了年龄,疾病持续时间和吸烟对视网膜结构的缓解作用.
突出了OCT作为神经生物学变化与精神病相关的生物标志物的潜力.

关键词:

双相情感障碍是双相情感障碍的一种疾病.马库拉 (Macula macula) 是一个很大的动物.周周毛囊 (Peripapillary) 是一个视网膜成像视网膜成像精神分裂症是一种精神分裂症.

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