年龄关联的更年期状态和性别相关差异与中年空间背景记忆和白质微观结构的年龄关联
Rikki Lissaman1, Sricharana Rajagopal2, Julia Kearley3
1Department of Psychiatry, McGill University, Montreal, QC, Canada.
Neurobiology of aging
|July 2, 2024
概括
中年更年期过渡影响空间记忆. 绝经后的女性表现出与年龄相关的大脑白质完整性和记忆力的下降,与男性或绝经前的女性不同.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 空间上下文记忆在中年期下降,与女性更年期过渡相吻合.
- 绝经后的女性表现出与年龄相关的大脑变化和记忆缺陷.
- 衰老对白质 (WM) 的影响及其对中年认知的性别差异的贡献尚未得到充分理解.
研究的目的:
- 调查中年成人空间背景记忆和白质微观结构的与年龄相关的变化.
- 检查这些年龄相关影响的性别差异,特别是关于更年期过渡的性别差异.
- 为了确定白质变化是否调解绝经后女性的认知变化.
主要方法:
- 该研究包括96名认知能力不受损的中年成人 (30名男性,32名绝经前女性,34名绝经后女性).
- 通过面部位置记忆任务评估空间上下文记忆.
- 使用扩散张力成像 (DTI) 评估的白质微观结构.
主要成果:
- 在绝经后的女性中,晚年与空间背景记忆的减少相关,但在绝经前的女性或男性中并非如此.
- 年龄较大与前额区域的白质微观结构变化有关 (例如前额冠状辐射,体基因).
- 额头白质的变化与较差的空间背景记忆有关,特别是在绝经后的女性中.
结论:
- 绝经后的状态似乎增加了对与年龄相关的白质变化的脆弱性.
- 这些白质变化可能会导致绝经后老年女性的情节性记忆障碍.
- 这些发现突出了更年期在调节大脑衰老和认知功能的作用.
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