面部-大脑相关性作为精神分裂症和双相情感障碍的潜在性别特异生物标志物
Noemí Hostalet1, Alejandro González2, Pilar Salgado-Pineda3
1FIDMAG, Germanes Hospitalàries Research Foundation, Barcelona, Spain; Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals (BEECA), Facultat de Biologia, Universitat de Barcelona (UB), Spain; CIBERSAM, Biomedical Research Network in Mental Health, Instituto de Salud Carlos III, Madrid, Spain.
Psychiatry research
|July 2, 2024
概括
面部形状的差异可能表明精神分裂症 (SZ) 和双相情感障碍 (BD) 的神经发育风险. 这些发现突出了这些条件下潜在的性别特异性脑脸相互作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症 (SZ) 和双相情感障碍 (BD) 涉及神经发育障碍.
- 面部和大脑的发育起源相同,这表明面部特征可能反映神经发育状态.
研究的目的:
- 调查与健康对照 (HC) 相比,SZ和BD患者的面部形状差异.
- 探索面部形态与大脑测量之间的关系.
- 检查这些协会中的性别特异性模式.
主要方法:
- 几何形态测量应用到3D面部重建.
- 基于里程碑的分析来量化全球和当地面部形状的变化.
- 面部和大脑皮层测量之间的相关性分析,按性别分层.
主要成果:
- 诊断占SZ的全球面部形状变异的4.1%-5.9%,BD的4.1%-4.5%.
- 与HC相比,在43.2%-47.4%的男性和47.4%-43.2%的女性中发现了显著的局部面部形状差异,SZ和35.8%-26.8%的BD,与HC相比.
- 大脑面积和体积解释了SZ男性的面部形状变异的2.2%-2%.
结论:
- 面部形状作为SZ和BD的潜在神经发育标志物.
- 结果表明,在这些疾病中,性别特定的机制影响了大脑-面部相互作用.
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