布洛芬可以将排卵推迟几个小时:在自然周期中进行了前性受控研究,其中HCG触发排卵
Michael von Wolff1, Gregory Reid2, Petra Stute3
1Division of Gynecological Endocrinology and Reproductive Medicine, University Women's Hospital, Inselspital, Berne, Switzerland..
Reproductive biomedicine online
|July 2, 2024
概括
布洛芬是一种非类固醇抗炎药物 (NSAID),可显著延迟女性的排卵. 试图怀孕的女性应该避免在排卵期间使用NSAID,尽管它们可能用于生育治疗.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 药理学 药理学是指药理学的学科.
背景情况:
- 排卵的时间对于怀孕至关重要.
- 非类固醇抗炎药物 (NSAIDs) 通常用于治疗疼痛和炎症.
研究的目的:
- 为了调查常见的NSAID - - 布洛芬是否会影响排卵的时间.
主要方法:
- 一项受控研究比较了接受试管婴儿治疗并服用布洛芬的女性与接受定时性交或IUI的对照组.
- 在hCG注射后42小时,通过测量未排卵的卵泡来评估排卵.
主要成果:
- 服用布洛芬的女性中有84.6%的排卵延迟,明显高于50%的参考值和对照组的20%.
- 在布洛芬组,延迟排卵的几率显著增加 (OR 22.72).
- 从有延迟排卵的女性中获取的卵子已经成熟 (转化阶段II).
结论:
- 试图在排卵期间怀孕的女性应该避免使用非选择性NSAIDs,如布洛芬.
- 如果需要,可以故意使用布洛芬来延迟辅助生殖技术中的排卵.
相关概念视频
Ovarian Cycle
1.1K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.1K
Birth Control Methods
226
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
226
Hormonal Regulation of the Menstrual Cycle
339
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
339
Hormonal Control of the Ovarian Cycle
461
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
461
Oogenesis
63.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.6K
In Vitro Fertilization
239
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
239


