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Updated: Jun 22, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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为c-ros瘤基因1 (ROS1) 发现一流的蛋白质降解剂

Jiawen Yang1, Yifan Wu2, Qiaoliang Zhu3

  • 1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; Shanghai Clinical Research and Trial Center, Shanghai 201210, China.

Bioorganic chemistry
|July 2, 2024
PubMed
概括

研究人员开发了SIAIS039,这是第一个PROteolysis-TTargeting Chimera (PROTAC) 来降解ROS1融合基蛋白. 这种新的方法在非小细胞肺癌 (NSCLC) 模型中显示出优异的抗瘤作用,为患者提供了新的希望.

关键词:
洛拉提尼布 (Lorlatinib) 是一种药物.非小细胞肺癌是非小细胞肺癌.这就是PROTAC.在ROS1上,它是ROS1的.目标蛋白质降解的目标蛋白质降解.

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