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经VX-509 (Decernotinib) 修改的宽容性树突细胞通过促进Th17/Treg再平衡来缓解实验性自身免疫神经炎

Juan Li1, Shan Chen1, Jiao Shi1

  • 1Clinical Laboratory, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu 610500, Sichuan, China; Department of Pharmacology, School of Pharmacy, Chengdu Medical College, Chengdu, 610500, Sichuan, China.

International immunopharmacology
|July 2, 2024
PubMed
概括

修改后的VX-509宽容性树突细胞 (VX-509-tolDCs) 缓解了吉兰-巴雷综合征 (GBS) 模型中的炎症性脱髓化病变. 这种疗法重新平衡T辅助细胞17 (Th17) 和调节性T细胞 (Treg),为GBS提供了潜在的治疗方法.

关键词:
实验性的自身免疫神经炎.吉兰 - 巴雷综合征是什么?在Th17细胞中.宽容性树突细胞是产生宽容性的.在Treg细胞中.在VX-509中使用.

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