在怀孕期间被诊断患有COVID-19的低风险患者中,新生儿出生体重是否减少?
Hannah S Foster1, Markolline Forkpa1, Ximena A Van Tienhoven2
1Department of Maternal Fetal Medicine, Pregnancy and Perinatal Research Center, University of Pennsylvania, Philadelphia, Pennsylvania.
American journal of perinatology
|July 2, 2024
概括
怀孕期间的COVID-19并没有影响低风险个体的婴儿出生体重. 这项研究发现,对于妊娠年龄小的新生儿的发育率相似,这表明这些患者不需要常规的生长超声波.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 新生儿健康 新生儿健康
背景情况:
- 2019年新型冠状病毒病 (COVID-19) 与妊娠前兆和早产等不良结果有关.
- COVID-19对胎儿异常生长的影响,特别是新生儿出生体重低,仍然不清楚.
- 对病毒对胎儿发育的影响的担忧促使建议在COVID-19的孕妇中进行第三季度超声波检查.
研究的目的:
- 为了比较COVID-19和没有COVID-19的低风险孕妇患者之间的新生儿出生体重.
- 为了确定第三季度生长超声波是否有必要用于COVID-19影响的低风险怀孕.
- 调查COVID-19在怀孕期间和妊娠年龄小 (SGA) 新生儿之间的关联.
主要方法:
- 对低风险孕妇的回顾性队列研究.
- 在怀孕期间和没有怀孕期间感染COVID-19的患者之间的比较.
- 收集有关人口统计,妊娠约会,新生儿出生体重和出生体重百分比的数据.
- 主要结局:出生时体重小于妊娠年龄 (SGA) 的新生儿被定义为出生时体重小于妊娠年龄 (SGA10) 的百分位数.
主要成果:
- 这项研究包括513名患者:有248人患有COVID-19,265人没有.
- 在分娩时的妊娠年龄或新生儿出生体重平均值之间没有观察到显著差异.
- 在COVID-19暴露 (8.9%) 和未暴露 (8.7%) 组中,SGA10新生儿的发病率相似.
- COVID-19的时间和严重程度与SGA率没有相关性.
结论:
- 在低风险怀孕中,COVID-19暴露并没有导致怀孕年龄较小的新生儿的发病率更高.
- 研究结果不支持在COVID-19的低风险孕妇中常规使用超声监测来限制胎儿生长.
- 这项研究澄清了COVID-19对胎儿生长的影响,指导了关于产前成像的临床实践.
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