在双胞胎和单胞胎分娩中,怀孕并发症的复发风险
Marion Granger1, Maria Sevoyan1, Nansi S Boghossian1
1Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.
American journal of perinatology
|July 2, 2024
概括
在随后的怀孕中,早产,妊娠期糖尿病和高血压疾病的复发风险增加. 单体单体怀孕显示出早产和妊娠糖尿病的最高风险,而双胞胎单体怀孕则具有患高血压疾病的最大风险.
科学领域:
- 生殖健康 生殖健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 周围生理学 周围生理学
背景情况:
- 怀孕并发症的复发,如早产 (PTB),妊娠糖尿病 (GDM),妊娠高血压 (GH) 和子宫前/子宫 (PE/E) 在随后的怀孕中存在风险.
- 了解这些风险对于有效管理和改善未来怀孕结果至关重要,特别是当涉及多胎时.
研究的目的:
- 估计和比较PTB,GDM,GH和PE/E的复发风险.
- 分析不同后续怀孕组的这些风险:单子-单子,双子-单子和单子-双子.
主要方法:
- 从NICHD连续怀孕研究 (2002-2010) 的数据分析.
- 包括至少有两次单独或双胞胎分娩的个人.
- 调整相对风险 (aRR) 的估计,使用具有强大的差异估计器的波桑回归模型.
主要成果:
- 在所有随后的怀孕组中,观察到PTB,GDM,GH和PE/E的复发风险增加.
- 单独怀孕的单独怀孕对PTB (aRR=5.1) 和GDM (aRR=22.7) 的复发风险最高.
- 双胞胎单子怀孕显示GH (aRR=7.6) 和PE/E (aRR=9.2) 的复发风险最高.
结论:
- 重大妊娠并发症的复发风险在所有随后的怀孕情景中都存在.
- 复发风险的大小受到指数或随后怀孕中倍数存在的显著影响.
- 这项研究为最初怀孕后的怀孕中风险分层和管理策略提供了关键数据,特别是那些涉及多胎的怀孕.
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