相关实验视频

Updated: May 2, 2026

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

开发3D打印的双释放固定剂量组合,通过双融挤压

Hye-Sung Oh¹, Jun-Bom Park¹

¹College of Pharmacy, Sahmyook University, Seoul 01795, Republic of Korea.

International journal of pharmaceutics

|July 2, 2024

概括

这项研究开发了一种3D打印的平板电脑,使用双融挤出技术打印了两种药物. 该技术成功地创造了一种双释放的固定剂量组合药片,具有不同的药物释放配置文件.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
药物输送系统药物输送系统

背景情况:

固定剂量组合 (FDC) 药片提供了改善的患者服药性和治疗疗效.
开发具有差异性药物释放配置文件的FDC给制造业带来了挑战.
3D打印技术可以实现具有复杂内部结构的定制药物输送系统.

研究的目的:

开发一种3D打印的FDC平板,使用双融挤出 (DME) 来分别释放乙氨基 (持续) 和布洛芬 (溶解).
调查DME的可行性,以创建适合3D打印的纤维,并将不同的药物纳入其中.
描述开发的3D打印FDC平板电脑的物理化学特性和药物释放行为.

主要方法:

双融挤出 (DME) 工艺在两个步骤中创建一个含有持续释放乙氨基和溶解布洛芬的单一丝.
在不同的温度下使用特定的聚合物 (Eudragit® S100,HPC-LF,Eudragit® EPO) 进行热挤出 (HME).
从制造的发光线中3D打印圆柱状平板.
在模拟的胃肠道条件下使用pH跳跃方法进行体外溶解试验.
使用TGA,DSC,PXRD,FTIR,SEM和CLSM进行物理化学表征.

主要成果:

通过使用DME,成功制造了一根含有持续释放乙氨基和溶解布洛芬的单一光纤.
制作一个9毫米圆柱形3D打印的FDC平板电脑,其中包含了不同的药物.
溶解试验证实了10小时内对乙氨基和布洛芬的分离释放概况.
物理化学分析证实了药物的稳定性,无形状态转化和药物在线索和片内独立分离.
SEM和CLSM证实,在发光线内存在持续释放的乙氨基颗粒.

结论:

双化挤出 (DME) 技术有效地用于为3D打印的固剂组合 (FDC) 平板电脑制造细丝.
开发的方法允许对乙氨基和布洛芬进行独立的结合和差异性释放.
这种方法为制造具有定制药物释放特性的先进3D打印FDC平板电脑提供了一个有前途的战略.

关键词:

通过3D打印打印的平板电脑.双化挤出方式双重释放药物的药物释放.固定的剂量组合.

更多相关视频

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Published on: June 27, 2014

Design of an Open-Source, Low-Cost Bioink and Food Melt Extrusion 3D Printer

Design of an Open-Source, Low-Cost Bioink and Food Melt Extrusion 3D Printer

Published on: March 2, 2020

相关概念视频

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...