益生菌组合通过修改肠道微生物群的组成,有效地改善怀孕期间的便秘
1National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, 529927Nanchang University, Nanchang 330031, China P.R.
Beneficial microbes
|July 2, 2024
概括
益生菌通过恢复肠道微生物群的多样性,显著改善了孕妇的便秘症状. 这种干预措施增强了肠道的规律性和便的一致性,提供了一个除了饮食和生活方式改变之外的有希望的治疗选择.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
背景情况:
- 怀孕便秘带来了流产和早产等风险.
- 有限证据表明,益生菌可以治疗与怀孕有关的便秘.
研究的目的:
- 评估益生菌在减轻怀孕期间便秘的疗效.
- 为了研究益生菌对肠道微生物群组成的影响,在便秘的孕妇.
主要方法:
- 一项涉及29名健康和65名便秘的孕妇的研究.
- 使用便秘严重程度量表 (CSS) 和布里斯托尔便量表 (BSS) 来评估症状.
- 使用16S rRNA测序来分析肠道微生物群的变化.
主要成果:
- 益生菌改善了CSS和BSS得分,增加了排便频率和改善了便特征.
- 16S rRNA测序显示肠道微生物群的多样性得到恢复.
- 有益的细菌 (Firmicutes,Actinobacteria,Faecalibacterium,Bifidobacterium) 的数量增加,而有害的细菌 (Bacteroidetes,Bacteroides,Prevotella) 的数量则减少.
结论:
- 益生菌通过增强肠道微生物群的多样性和恢复微生物平衡,有效地缓解妊娠便秘.
- 益生菌对妊娠便秘的缓解效果比饮食和生活方式的改变更强.
- 提供使用益生菌治疗怀孕期间便秘的临床数据和理论基础.
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