间歇性感染作为系统性红血狼患者疾病爆发的危险因素
Fatma El Hadiyen1, Michel W P Tsang-A-Sjoe2, Birgit I Lissenberg-Witte3
1Department of Rheumatology, Amsterdam Rheumatology and immunology Center, Amsterdam UMC, Amsterdam, Noord-Holland, the Netherlands.
Lupus science & medicine
|July 2, 2024
概括
感染增加了系统性红斑狼 (SLE) 患者疾病爆发的风险. 主要感染显著增加了主要SLE爆发的可能性,支持感染触发SLE活动的假设.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病.
- 疾病爆发是SLE管理中的一个重大问题.
- 间流传染病作为SLE爆发的触发因素的作用需要进一步调查.
研究的目的:
- 调查感染是否是SLE患者随后疾病爆发的危险因素.
- 量化感染和SLE爆发之间的关联.
主要方法:
- 研究了203名SLE患者的队列.
- 关于感染和SLE爆发 (轻微和重大) 的数据是通过注册表收集的.
- 使用具有反复事件和时间变化的共变量的比例危险模型.
主要成果:
- 大型/小型感染的发病率为每100个患者年5.3/63.9.
- 大型/小型爆发的发病率为每100个患者年3.6/15.1.
- 间歇性感染与SLE爆发相关 (HR 1.9). 主要感染显著增加了重大爆发的风险 (HR 7.4).
结论:
- 间歇性感染与随后的SLE爆发有关.
- 这些发现支持了感染可以引发SLE爆发的假设.
- 这凸显了SLE患者感染管理的重要性.
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