通过3D打印酸的药物输送策略通过3D打印酸
Vishal S Chaudhari1, Priya Kushram1, Susmita Bose1
1W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
Trends in biotechnology
|July 2, 2024
概括
本综述探讨了用于骨组织工程的3D打印酸支架,重点关注先进的药物输送方法,以改善骨再生和克服像爆发释放这样的局限性.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 药物输送系统 药物输送系统
背景情况:
- 通过3D打印,可以为患者提供骨再生的特定支架.
- 酸 (CaP) 对骨移植具有重要意义,因为它具有生物相容性和生物降解性.
- 3D打印的CaP支架通过多孔结构和可控溶解提供精确的药物输送.
研究的目的:
- 审查骨组织工程中3D打印的CaP支架的多功能药物输送方法.
- 为应对传统基架药物输送的挑战,如突发释放和药物损失.
主要方法:
- 总结了各种药物输送控制策略.
- 包括聚合物涂层,配方集成,微孔支架设计,化学交叉连接和直接挤出印刷.
- 专注于骨组织工程 (BTE) 的应用.
主要成果:
- 确定了多种策略来控制3D打印的CaP支架中的药物释放.
- 突出了这些支架在增强骨再生方面的潜力.
- 解决了传统药物输送系统的局限性.
结论:
- 多功能药物输送方法对于下一代骨修复至关重要.
- 需要进一步的研究来克服基架药物输送方面的挑战.
- 通过3D打印的CaP支架显示了先进的骨再生疗法的前景.
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