[从呼吸道样本来源获得的Streptococcus agalactiae的分子特征和药物敏感性分析]
1North China University of Science and Technology Affiliated Hospital, Tangshan 063000, China National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing 102206, China.
概括
来自呼吸道样本的Streptococcus agalactiae主要影响老年患者,CC10/ST10菌株是最常见的. 这些细菌对宏类,林科萨米德和诺具有显著的耐药性,构成显著的健康风险.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 甲状杆菌 (B组甲状杆菌) 是一个重要的人类病原体.
- 由S. agalactiae引起的呼吸道感染越来越多地得到认可,特别是在脆弱人群中.
- 了解来自呼吸道来源的S. agalactiae的遗传和表型特征对于有效的治疗和控制至关重要.
研究的目的:
- 从呼吸器样本中调查S. agalactiae的药物易感性,克隆复合体,血清型,表面蛋白质和毒性基因.
- 在患有呼吸道感染的老年患者中描述S. agalactiae菌株的流行率和遗传构成.
主要方法:
- 从两个地点的呼吸器标本收集了35个S. agalactiae菌株.
- 使用微稀释方法进行抗菌素敏感性测试.
- 全基因组测序用于识别耐药性基因,克隆组,血清型,类型,表面蛋白质和毒性因子.
主要成果:
- S. agalactiae菌株对青素,线化物,万科米辛和 ceftriaxone 显示了100%的敏感性.
- 对于红红素 (97.1%),克林达胺素 (85.7%) 和乐沃素 (82.9%) 观察到高耐药率.
- CC10/ST10克隆组 (62.8%) 和Ib血清型 (65.7%) 主导. 检测到多个耐药性 (ermB,tetM) 和毒性基因 (cylE, hylB),以及 gyrA 和 parC.中的高突变率.
结论:
- 呼吸道S. agalactiae分离物主要来自老年患者,其中CC10/ST10菌株最为普遍.
- 这些菌株表现出显著的多药性耐药性,特别是对宏类,林科萨米德和类的耐药性.
- 这些发现凸显了对S. agalactiae在老年人呼吸道感染中构成的健康威胁的提高警的必要性.
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