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[炎症相关基因在支气管肺功能障碍的诊断价值]

Y Wen¹, J F Zhang¹, S Q Shang¹

¹Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310052, China.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

|July 2, 2024

概括

这项研究确定了外围血液单核细胞中的关键炎症相关基因,可以诊断新生儿的支气管肺功能障碍症 (BPD). 使用这些基因的预测模型在区分BPD病例方面显示出高准确度.

科学领域:

基因组学就是基因组学.
新生儿医学新生儿医学
生物信息学是一种生物信息学.

背景情况:

支气管肺功能障碍症 (BPD) 是早产婴儿的一种严重并发症.
早期和准确的BPD诊断对于及时干预和改善结果至关重要.

研究的目的:

为了研究BPD的外周血液单核细胞中与炎症相关的基因的诊断价值.
利用这些基因开发和验证BPD诊断的预测模型.

主要方法:

对251名新生儿的三个全基因组表达数据集 (GSE32472,GSE125873,GSE220135) 的生物信息学分析.
使用GSEA和MRA识别差异表达的基因和丰富的与炎症相关的途径.
开发基于后勤回归的风险评分模型和使用曲线下的面积 (AUC) 的评估.

主要成果:

与对照组相比,在BPD新生儿中发现了486个上调和433个下调的基因.
在BPD病例中,与炎症相关的途径显著丰富.
一个包含PLCB1,NID1,SRFBP1,CEP72,ERCC6L和PPIL1的预测模型在独立测试数据集中实现了0.88,0.86和0.89的AUC.

结论:

已识别的与炎症相关的基因和开发的风险评分模型证明了BPD的显著诊断价值.
这种基于基因的预测模型为区分BPD新生儿提供了一个有前途的工具.
需要进一步验证,以便将该模型纳入BPD诊断的临床实践.

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