成年人维生素D和糖尿病前期之间关系的性别差异:一个横截面研究
Ali H Ziyab1, Anwar Mohammad2, Zainab Almousa3
1Department of Community Medicine and Behavioral Sciences, College of Medicine, Kuwait University, Safat, Kuwait. ali.ziyab@ku.edu.kw.
低维生素D水平会增加男性的糖尿病前期风险,但不是女性. 这种性别相关性在维生素D水平低于35nmol/L时最明显,突出了糖尿病前期患病率的差异.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏是常见的,并且与糖尿病前期风险有关.
- 关于性别是否影响维生素D与糖尿病前期关系的证据有限.
- 对有针对性的干预措施来说,调查特定性别的关联是至关重要的.
研究的目的:
- 为了检查维生素D状态和糖尿病前期之间性别特定的关联.
- 为了确定性别是否会改变25-氧维生素D水平与糖尿病前期患病率之间的关系.
主要方法:
- 来自科威特福祉研究的非糖尿病成年人的横截面研究.
- 糖尿病前期是由HbA1c水平 (5.76.4%) 定义的.
- 维生素D (25(OH) D) 连续分析,二分法,和分类,与性别分层分析.
主要成果:
- 观察到性别和25(OH) D状态之间存在显著的相互作用 (P < 0.05).
- 维生素D缺乏的男性 (<50nmol/L) 患糖尿病前期的患病率增加了2.35倍.
- 在女性中没有发现任何显著的关联,在25...OH) D水平≤35nmol/L时,性别差异明显.
结论:
- 性行为显著改变了维生素D水平和糖尿病前期之间的关联.
- 在男性中发现了维生素D和糖尿病前期之间的反向关联,但在女性中没有.
- 与维生素D相关的糖尿病前期患病率的性别差异在维生素D水平较低时最为明显.
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