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Updated: Jun 22, 2025

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全外基因组测序识别了29828个个体中与大脑铁相关的蛋白质编码变体

Weikang Gong1,2, Yan Fu3, Bang-Sheng Wu4

  • 1School of Data Science, Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. weikanggong@fudan.edu.cn.

Nature communications
|July 2, 2024
PubMed
概括

这项研究使用外体全方位分析识别了与大脑铁水平相关的36个基因. 它揭示了大脑铁与帕金森病和抑郁症等疾病之间的因果关系,提供了新的治疗点.

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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