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Updated: Jun 22, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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内在信号通路调节向的蛋白质降解

Yuki Mori1,2, Yoshino Akizuki1,2, Rikuto Honda1,2

  • 1Laboratory of Protein Degradation, Institute for Advanced Life Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.

Nature communications
|July 2, 2024
PubMed
概括

通过抑制细胞信号通路,可以增强向蛋白质降解. 抑制PARG,PERK和HSP90的抑制剂促进了癌症点的降解,如BRD4,使细胞对细胞亡敏感.

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