关注的转变驱动在决策过程中在小鼠前带皮层的上下文依赖子空间编码
Márton Albert Hajnal1, Duy Tran2,3, Zsombor Szabó4
1Department of Computational Sciences, HUN-REN Wigner Research Centre for Physics, Budapest, Hungary. hajnal.marton@wigner.hun-ren.hu.
Nature communications
|July 2, 2024
概括
这项研究揭示了前带状皮质 (ACC) 如何内部构建注意力信号. 在ACC中,相互抑制的神经连接会抑制不相关的信息,在相关性不由外部决定时,有助于决策.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 注意对于决策至关重要,涉及选择性增强相关刺激和抑制干扰因素.
- 引起注意的神经机制,特别是当相关性必须在内部构建时,仍然不太了解.
研究的目的:
- 为了研究前带状皮质 (ACC) 在刺激相关性转变时如何产生注意力信号.
- 阐明内部驱动的注意力和上下文抑制的神经动力学.
主要方法:
- 在注意力转移任务期间,从小鼠 ACC 中的神经元群体中记录的神经活动.
- 利用分析证据和循环神经网络 (RNN) 模型来分析神经数据和任务动态.
- 将ACC神经活动与视觉皮层的记录进行比较 (V1).
主要成果:
- 在ACC中,与V1.1不同的是,无关的感觉模式的解码在ACC中逐渐下降.
- 在ACC中确定了相互抑制的连接,导致了上下文关闭的抑制.
- 预测并证实了神经上下文调制和ACC中的刺激驱动之间的相关性.
结论:
- 该ACC在内部构建注意力信号的关键作用通过上下文关闭的抑制.
- 在ACC中相互抑制的神经回路对于基于内部环境的动态调整注意力至关重要.
- 研究结果提供了关于在变化的相关性条件下灵活决策的神经基础的见解.
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