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Updated: Jun 22, 2025

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鼠标星球细胞的直接神经元重编程与多层次的表观基因组重塑有关,并且需要Yy1进行重编

Allwyn Pereira1,2,3, Jeisimhan Diwakar1,4, Giacomo Masserdotti1,2

  • 1Biomedical Center Munich (BMC), Physiological Genomics, LMU Munich, Planegg, Germany.

Nature neuroscience
|July 2, 2024
PubMed
概括

直接神经元重编程使用Neurogenin2 (Ngn2) 将质细胞转化为神经元. 这项研究揭示了Yy1是与Ngn2相互作用的关键辅因子,增强了神经元再生的表观遗传重塑和重编程效率.

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