在正常或亚临床功能障碍范围内,TSH和甲状腺激素与左心室透静功能障碍的相关性
Ji Eun Jun1, Tae Hyuk Kim2, Sun Wook Kim3
1Department of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Scientific reports
|July 2, 2024
概括
亚临床的甲状腺功能低下,但不是亚临床的甲状腺毒性,与左心室扩张性功能障碍有关. 甲状腺激素T3水平在正常范围内也会影响透缩功能,突出显示甲状腺状况.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 甲状腺学 甲状腺学
背景情况:
- 甲状腺激素显著影响心血管功能.
- 亚临床甲状腺功能障碍和甲状腺甲状腺激素水平对心脏功能的确切影响仍然不完全理解.
- 左心室 (LV) 扩张功能障碍是心脏健康的关键指标.
研究的目的:
- 为了研究亚临床甲状腺功能障碍和 LV 扩张功能障碍之间的关联.
- 探索甲状腺激素在正常参考范围和心脏功能之间的关系.
- 澄清亚临床甲状腺功能低下症和亚临床甲状腺毒性病在扩张功能障碍中的作用.
主要方法:
- 这是一项涉及韩国26289名参与者的横截面研究.
- 根据甲状腺刺激激素 (TSH),自由甲状腺素 (FT4) 和三甲状腺素 (T3) 水平,参与者被分为乙甲状腺,亚临床甲状腺功能低下症和亚临床甲状腺毒性小组.
- 用心声学评估心脏结构和功能,特别是心脏静脉静脉扩张功能障碍.
主要成果:
- 亚临床甲状腺功能低下症与增加 LV 扩张功能障碍的几率显著相关 (调整后几率比率 [AOR] 1.36).
- 亚临床甲状腺毒性并没有显示出与LV透气功能障碍的显著关联.
- 在正常范围内的血清三甲氨酸 (T3) 水平与 LV 扩张功能障碍相反相关,这表明它比 TSH 或 FT4 有更重要的作用.
结论:
- 亚临床甲状腺功能低下症是发展左心室扩张功能障碍的重要危险因素.
- 亚临床甲状腺毒毒症似乎与LV的透气功能障碍无关.
- 血清T3水平,即使在正常范围内,也在调节LV透缩功能方面发挥着显著的作用.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
01:18Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
01:17Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K