关于堕胎的父母决定与胎儿心脏病的严重程度之间的关联
Masahiro Nakao1,2, Masanari Kuwabara3, Mika Saito4
1Department of Obstetrics and Gynecology, Sakakibara Heart Institute, Tokyo, Japan. hiro.nakao1987@gmail.com.
Scientific reports
|July 2, 2024
概括
关于终止胎儿心脏病怀孕的父母决定受到诊断时间和疾病严重程度的影响. 死亡率和心脏外问题增加了堕胎的可能性,而复杂性并没有显著影响选择.
科学领域:
- 医学遗传学 医学遗传学
- 心脏病学 心脏病学
- 生殖健康 生殖健康
背景情况:
- 胎儿心脏病 (FHD) 的产前诊断显著影响父母关于终止怀孕的决定.
- 现有研究强调疾病严重程度是关键因素,但最近手术结果的进步需要进一步调查.
- 了解FHD严重程度如何影响这些关键决策的细微差别至关重要.
研究的目的:
- 调查影响父母对胎儿心脏病产前诊断后堕胎决策的风险因素.
- 分析妊娠年龄在诊断时的影响,疾病的关键性,复杂性和心脏外/遗传异常对父母的选择.
主要方法:
- 在怀孕22周之前对73个怀孕的逆向分析,产前FHD诊断.
- 怀孕的分类分为终止 (n=37) 和继续 (n=36) 组.
- 统计建模 (逻辑回归) 用于确定决策因素的赔率比率和置信区间.
主要成果:
- 诊断时妊娠年龄增加与终止妊娠的可能性降低有关 (aOR 0.94-0.95).
- 临界疾病 (aOR 5.25) 和并发的心脏外或遗传异常 (aOR 4.19-5.47) 显著增加了选择堕胎的可能性.
- 疾病复杂性没有显著影响父母的决定 (aOR 0.56).
结论:
- 父母对FHD妊娠终止的决定受到早期诊断,疾病致死率和同时出现的异常的影响.
- 疾病复杂性本身似乎不是这些决定的重要因素.
- 在专门中心进行有效的产前诊断和咨询,可以帮助父母做出决定.
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