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入院泛免疫炎症值与败血症患者的短期死亡率之间的关联:一个回顾性队列研究
Hong-Bo Xu1, Yu-Hong Xu2, Ying He3
1Department of Critical Care Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital/The 6th Affiliated Hospital of Shenzhen University Health Science Center, 89 Taoyuan Road, Shenzhen, 518052, China.
Scientific reports
|July 2, 2024
概括
全免疫-炎症值 (PIV) 显示了败血症患者与死亡率的非线性关联. 较高的PIV水平与增加的28天和90天死亡风险相关,表明其预后价值.
科学领域:
- 关键护理医学 关键护理医学
- 炎症生物标志物 炎症生物标志物
- 败血症病理生理学病理生理学
背景情况:
- 全免疫炎症值 (PIV) 是一个新兴的炎症指标.
- 败血症是一种危及生命的疾病,死亡率高.
- 预后标志物对于治疗败血症患者至关重要.
研究的目的:
- 为了研究PIV与败血症患者的预后之间的关联.
- 为了确定PIV是否可以预测败血症的死亡率.
- 探索PIV和死亡结果之间的关系的性质.
主要方法:
- 来自MIMIC-IV数据库的11,331名败血症患者的回顾性分析.
- 卡普兰-梅尔曲线以评估基于PIV的生存率.
- 多变量考克斯回归和受限立方脊柱分析,以评估PIV与28天和90天死亡率的关联.
主要成果:
- 较高的PIV水平与较低的28天生存率有关.
- 逻辑2-PIV显示了与28天死亡风险的积极,非线性关联.
- 在log2-PIV=8的拐点表明较高值的死亡风险增加,90天死亡率的趋势类似.
结论:
- PIV显示,在败血症患者中,与28天和90天的死亡率有显著的非线性关系.
- 在败血症管理中,PIV可以作为一个有价值的预后生物标志物.
- 需要进一步的研究来阐明PIV在败血症中的临床效用.
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