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Updated: Jun 22, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Published on: May 6, 2019

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DOK1和DOK2调节CD8T细胞信号传递和记忆形成,而不会影响瘤细胞的杀死

Vladimir Laletin1, Pierre-Louis Bernard1, Camille Montersino2

  • 1Centre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille University, Marseille, France.

Scientific reports
|July 2, 2024
PubMed
概括

在CD8+ T细胞中削减DOK1和DOK2蛋白质可以增强效应器记忆形成和T细胞受体信号传递. 然而,这种消耗在体外并没有改善抗癌活性.

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