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Updated: Jun 22, 2025

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环境的昼夜干扰重写肝脏的昼夜蛋白质组

Hao A Duong1,2, Kenkichi Baba3,4, Jason P DeBruyne3,4

  • 1Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA, 30310, USA. hduong@msm.edu.

Nature communications
|July 2, 2024
PubMed
概括

环境 - 循环节障碍 (ECD) 显著改变肝脏基因表达节奏,影响新陈代谢. 即使在康复后,这些变化仍然存在,这突显了被破坏的生理节律时钟的持久影响.

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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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