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在COVID-19期间,外周血液单核细胞中ACE2表达的减少 - - 对COVID-19后的条件的影响

Gulrayz Ahmed¹, Yasir Abdelgadir¹, Amro Abdelghani¹

¹Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

BMC infectious diseases

|July 3, 2024

概括

严重的COVID-19患者在血液细胞中很少表达血管酶转化酶2 (ACE2) RNA,与健康个体不同. 这一发现,以及纤维化和血管病变标记的升高,表明有助于COVID-19后条件的途径.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
病理生理学病理生理学

背景情况:

严重的COVID-19影响了少数人群.
对疾病严重程度和COVID-19后条件 (PCC) 的研究生物标志物.
专注于血管激素转化酶2 (ACE2) 的表达变异性.

研究的目的:

为了确定血液中的ACE2表达是否表明COVID-19的严重程度.
探索ACE2,TIMP-1,PIIINP和MMP-9在PCC病变发生过程中的作用.
了解PCC发展的生物学可信性.

主要方法:

将严重的COVID-19患者与健康对照进行比较.
在外周血液单核细胞 (PBMC) 中测量了ACE2RNA表达.
量化血ACE1,ACE2酶活动,以及TIMP-1,PIIINP,MMP-9抗原.

主要成果:

在严重的COVID-19患者中很少检测到ACE2RNA,但在对照组中很常见.
ACE2RNA表达与血ACE1/ACE2活性没有相关性.
观察到纤维化 (TIMP-1,PIIINP) 和血管病变 (MMP-9) 的标志物升高.

结论:

ACE2,TIMP1,PIIINP和MMP-9在PCC病变发生过程中显示出生物和时间的可信性.
这些系统的交叉是不常见的,可能解释PCC稀有性.
暗示了PCC中涉及氨酸 - ангиотензин系统,纤维化和血管病变的神秘过程.

关键词:

ангиотензин转化酶 2; 转录转录在 COVID-19 疫情中,遗传学遗传学是一种遗传学.白血球是白血球的细胞.矩阵金属蛋白酶-9-9的作用单核; 生物标志物在N端的Procollagen III中.后急性COVID-19综合征是什么金属蛋白-1酶的组织抑制剂.

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