基于Box-Behnken实验设计,标准关系和FAHP-CRITIC方法,优化了州太井粉的提取过程
Mengcheng Jiang1, Zhidong Qiu1, Yuanyuan Diao1
1College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.
BMC complementary medicine and therapies
|July 3, 2024
概括
优化采用现代方法提取州泰粉 (STP) 确保了一致的质量. 一种结合Box-Behnken响应表面和FAHP-CRITIC方法的新方法实现了这个古老的中国医学的最佳提取参数.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 传统中国医学 (TCM) 研究研究
- 过程化学 过程化学
背景情况:
- 古老的经典处方对于TCM的保存和进步至关重要.
- 确保传统和现代开采工艺之间的质量一致性存在重大挑战.
- 这项研究的重点是优化州太义粉 (STP) 的提取,这是一个古老的经典处方.
研究的目的:
- 开发和验证州泰粉 (STP) 的现代提取工艺.
- 在从传统制造业过渡到现代制造业时,确保产品质量的一致性.
- 通过使用强大的方法方法方法,为STP建立最佳的提取参数.
主要方法:
- 使用Box-Behnken响应表面方法来优化提取参数 (水比,持续时间,提取次数).
- 整合了标准关系,模糊分析层次过程 (FAHP) 和通过参数权重的标准关联 (CRITIC) 方法来确定标准的重要性.
- 作为关键评价指数,采用了迷酸,异 Imperatorin,puerarin含量,提取产量和指纹相似性.
主要成果:
- 确定STP的最佳提取条件是两个提取,每次为一个小时的十倍水比.
- 在三个批次的工艺验证显示出高稳定性,达到94.7的综合得分,相对标准偏差为0.76%.
结论:
- 联合的Box-Behnken响应表面和FAHP-CRITIC方法是优化TCM提取过程的稳定和可行的方法.
- 这种方法成功优化了州泰粉的提取,确保了质量的一致性.
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