结合德克斯梅德托米丁的埃斯基他胺对机械通风ICU患者镇静时的妄想的影响:随机对照试验中的嵌套子研究协议
Wenhui Zhang1, Jinjin You1, Jing Hu2
1Department of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Trials
|July 3, 2024
概括
这项研究调查了结合deksmedetomidine和esketamine是否可以减少机械通风患者的妄想. 目标是通过减轻德克斯梅德米丁的作用来改善结果.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 镇静剂和止痛药,包括德克斯梅德托米丁,与机械通风患者的妄想有关.
- 德克斯梅德托米丁的使用可能会导致低血压,心,和不充分的镇静,需要替代策略.
- 现有证据表明,在这个人群中治疗狂妄症的埃斯基坦胺-德克斯梅德托米丁组合是有限的.
研究的目的:
- 与单独使用德克斯梅托米丁相比,评估结合德克斯梅托米丁和埃斯基坦胺在减少痴呆症发生方面的有效性.
- 评估这种组合是否能减轻与机械通风ICU患者德克斯梅德托米丁单一治疗相关的副作用.
- 通过这种新的组合疗法,提供证据来改善短期预后.
主要方法:
- 一个单中心,随机,主动控制的优越性试验,涉及134名机械呼吸患者.
- 随机分配的患者接受单独的德克斯梅德托米丁或埃斯基坦胺和德克斯梅德托米丁的组合,直到输出或14天.
- 主要结局:妄想的发生率. 二次结局包括没有妄想的日子,严重程度,持续时间,血管压缩剂/抗精神病药物的使用,通风持续时间,ICU/医院LOS和死亡率.
主要成果:
- 关于妄想发生的初级结果数据正在等待.
- 目前正在进行二次结果数据收集,包括没有妄想的日子,镇静水平和生理参数.
- 对血管压缩剂使用,通风持续时间和患者结果的分析将在研究完成后报告.
结论:
- 需要改进镇静剂治疗方案,以控制机械通风患者的妄想.
- 乙胺和德克斯梅德托米丁的组合显示出降低痴呆症及其相关并发症的潜力.
- 这项研究的目的是提供关键证据,支持在ICU患者中使用乙胺-德克斯米德米丁以获得更好的结果.
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