在心房的患者中,左心房基质的性别相关差异:来自高密度电压映射的证据
Wenchao Huang1, Huaxin Sun1, Shiqiang Xiong1
1Department of Cardiology, The Third People's Hospital of Chengdu, 82 Qinglong St, Chengdu, 610031, Sichuan, China.
European journal of medical research
|July 3, 2024
概括
与男性相比,患有心房的女性在切除后表现出较低的心房电压和更高的复发率. 这些心房基质和结果的性别相关差异在阳性肌痛中突出,表明潜在的病理生理因素.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 医学中的性别差异.
背景情况:
- 与男性相比,患有心房的女性经历了更大的症状负担和更高的复发率.
- 在AF中观察到的这些性别差异的潜在机制仍然不清楚.
研究的目的:
- 研究心房电生理学基质的性别相关差异和AF患者的临床结果.
- 确定可能导致女性AF复发率更高的潜在因素.
主要方法:
- 预期招募125名患者 (40名非AF,85名AF) 接受高密度电压映射.
- 在鼻腔节律和AF期间对心房电压的分析,与性别和AF类型相关.
- 导管切除后复发率的评估,按性别和AF类型分层.
主要成果:
- 与男性AF患者相比,女性AF患者的心房电压显著降低 (P=0.003),非AF患者没有性别差异.
- 女性性别独立地与较低的心房电压相关 (P=0.004).
- 与男性相比,患有阳性AF的女性的复发发病率是男性的3.5倍 (aHR=4.49,P=0.036).
结论:
- 对心房基质和无心律失常生存率的性别相关差异在 Paroxysmal AF 患者中很明显.
- 研究结果表明,存在与性别相关的病理生理因素,影响AF进展和治疗结果.
- 需要进一步的研究,以阐明驱动这些性差异在AF的具体机制.
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