维生素K:危急疾病中的潜在缺失环节 - - 范围审查
Michelle Carmen Paulus1,2, Marjolein Drent3,4,5, Imre Willemijn Kehinde Kouw1,2
1Department of Intensive Care Medicine & Research, Gelderse Vallei Hospital, Willy Brandtlaan 10, 6716 RP, Ede, The Netherlands.
Critical care (London, England)
|July 3, 2024
概括
维生素K缺乏症在重症患者中很常见,影响凝血并增加风险. 需要进一步的研究,以确定在重症监护病房中最佳的维生素K补充策略.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 维生素K对凝血,骨代谢和抗氧化功能至关重要.
- 维生素K缺乏在重症患者中很普遍,增加出血风险.
- 了解维生素K的新陈代谢对于管理严重疾病并发症至关重要.
研究的目的:
- 对重症患者的维生素K代谢进行审查.
- 为了确定维生素K缺乏的潜在治疗策略.
- 为了阐明维生素K缺乏在ICU环境中的患病率和进展.
主要方法:
- 在2023年12月进行了范围审查.
- 在PubMed,Embase和Cochrane数据库中进行了搜索.
- 纳入标准侧重于维生素K缺乏或补充维生素的成年ICU患者的讨论.
主要成果:
- 在1712篇选文章中,有13项研究符合纳入标准.
- 在ICU患者中,维生素K缺乏与营养不良,吸收受损和抗生素使用有关.
- 补充维生素K可以改善状态,但不能完全使其正常化;缺乏与更糟糕的结果相关.
结论:
- 在ICU患者中解决维生素K缺乏症至关重要.
- 最佳的管理和补充策略需要进一步研究.
- 本综述为在重症监护中诊断和管理维生素K缺乏提供了指导.
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