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Updated: Jun 22, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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肯尼亚癌症儿童暴露于温克里斯:CHAPATI可行性研究

Aniek Uittenboogaard1,2, Mirjam van de Velde1, Lisa van de Heijden3,4

  • 1Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Pediatric blood & cancer
|July 3, 2024
PubMed
概括

肯尼亚儿童的温克里斯暴露率很高,与预期相反. 尽管如此,没有参与者发展出因温克里斯诱导的外围神经病变 (VIPN),这表明目前的剂量可能是安全的.

关键词:
可行性研究可行性研究.个性化剂量 个性化剂量儿科瘤学 儿科瘤学药物动力学 药物动力学撒哈拉以南非洲地区.维克里斯蒂娜 维克里斯蒂娜

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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