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Updated: May 5, 2026

Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance SPR
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Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance SPR

Published on: November 29, 2014

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在可开发性研究中,通过基于表面等离子体共振的相对结合活性评估,早期确定治疗抗体的潜在关键质量属性

Shuai Wang1,2, Yanqiu Wang1,2, Zhenzhen Li1,2

  • 1State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China.

mAbs
|July 3, 2024
PubMed
概括

一种新的表面等离子体共振 (SPR) 方法精确地测量治疗抗体结合活性,识别关键质量属性 (CQAs),如影响药物的疗效和稳定性的脱amidation.

关键词:
开发抗体的发展.关键质量属性是关键的质量属性.开发能力评估 开发能力评估强制降解降解的强制性降解相对约束性活动的相对约束性.表面的等离子体共振.治疗性抗体治疗性抗体

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Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
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