基于HINODE除器患者的生理传感器数据预测心力衰竭事件
Nobuhiro Nishii1, Yasushi Sakata2, Toyoaki Murohara3
1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
ESC heart failure
|July 3, 2024
概括
HeartLogic算法成功地检测到心力衰竭事件 (HFEs) 的恶化,灵敏度为80.8%,使得早期干预成为可能. 这种远程监控工具预测风险增加,可能减少心力衰竭患者住院治疗.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 远程监控患者 远程监控患者
背景情况:
- 心力衰竭住院经常发生,导致高死亡率,再入院和经济负担.
- 早期发现恶化的心力衰竭 (HF) 对于及时干预和减少住院治疗至关重要.
- 心灵逻辑算法利用多传感器设备数据来预测即将发生的高频恶化.
研究的目的:
- 评估HeartLogic算法在预测心力衰竭事件 (HFEs) 中的灵敏度.
- 为了评估HeartLogic算法的假阳性警报率 (FPR).
- 为了比较患有和没有HeartLogic警报的患者中HFEs的发病率.
主要方法:
- 在HINODE研究中,有144名患者 (ICD/CRT-D) 获得了远程监测数据.
- 心灵逻辑警报被追溯模拟;临床医生和患者对警报是盲目的.
- 独立委员会对HFE进行了裁决; 计算了灵敏度,FPR和事件率.
主要成果:
- 心灵逻辑算法检测到名义值的HFE的80.8%.
- 在警报状态下,HFE的发生率是警报状态下的8.4倍,而非警报状态的8.4倍 (P < 0.001).
- 错误的阳性警报率为每年患者1.16个警报.
结论:
- 使用HeartLogic远程监测患者,成功检测到恶化的心力衰竭的早期迹象.
- 该算法可以预测风险增加的时期,促进早期干预.
- 在心力衰竭患者群体中,HeartLogic具有减少住院的潜力.
相关概念视频
01:17Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K
01:30Pulse rhythm
782
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
782
01:26Heart Failure Drugs: Inotropic Agents
564
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
564