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Updated: Jun 22, 2025

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通过光诱导的超极化NMR快速确定蛋白质 - 连接体亲和力

Matthias Bütikofer1, Gabriela R Stadler1, Harindranath Kadavath1

  • 1Institute for Molecular Physical Science, Vladimir Prelog Weg 2, 8093 Zürich, Switzerland.

Journal of the American Chemical Society
|July 3, 2024
PubMed
概括

我们开发了一种使用光化学诱导的动态核极化 (光CIDNP) NMR的快速方法, 这种技术通过提供精确的亲和度测量和结合性表位信息,显著加速早期药物发现.

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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)01:15

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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