25 复发性复发性硬化症患者的氧维生素D和细胞因子概况
Georgi S Slavov1, Mariya G Manova1, Ivanka I Kostadinova2
1Department of Neurology, Medical University of Plovdiv, Plovdiv, BGR.
Cureus
|July 3, 2024
概括
多发性硬化症患者的细胞因子水平在复发和缓解期间显示出免疫失衡. 在复发期间增加的促炎性细胞因子与疾病严重程度相关,而抗炎性细胞因子在缓解期间得到改善.
科学领域:
- 神经免疫学 神经免疫学
- 临床免疫学 临床免疫学
背景情况:
- 在实验性过敏性脑膜炎和多发性硬化症 (MS) 中,轴突损失与细胞毒性T细胞 (CD8 T) 和炎症活性有关.
- 了解细胞因子动态对于阐明MS病理机制至关重要.
研究的目的:
- 在患有复发性复发性MS的患者中,评估复发和缓解期间的血清亲和抗炎细胞因子度.
- 评估细胞因子水平,疾病活性和残疾之间的关系.
主要方法:
- 一项涉及46名多发性硬化患者和40名健康对照者的病例控制研究.
- 使用酶相关免疫吸收试验 (ELISA) 测量血清细胞因子水平.
- 细胞因子水平,扩大残疾状态量表 (EDSS) 和25-氧维生素D (25(OH) D) 之间的相关性分析.
主要成果:
- 与对照组相比,在MS患者中观察到显著的免疫失衡.
- 在复发期间增加的干扰素- (IFN-γ) (p=0.017).
- 缓解期间转化生长因子-β (TGF-β) 和IL4 (IL4) 的增加 (p=0.006; p=0.009).
- 在复发期间,瘤亡因子-α (TNF-α) 和EDSS之间的相关性 (p=0.042).
- 在恶化期间,介质蛋白17 (IL17) 和25-氧维生素D (25(OH) D之间的中等关系 (p=0.02).
结论:
- 血清中TNF-α,IFN-γ,IL17和TGF-β水平作为MS复发和缓解中的免疫炎症活性指标.
- 细胞因子概况反映了疾病状态和潜在的治疗点.
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