在暗示情绪调节期间,污染负担对神经功能的影响以及青少年抑郁症状的纵向变化
Jessica P Uy1, Justin P Yuan1, Natalie L Colich2
1Department of Psychology, Stanford University, Stanford, California.
Biological psychiatry global open science
|July 3, 2024
概括
青春期早期的环境污染与大脑功能变化有关,特别是在默认模式网络中. 这种在情绪调节期间大脑活动的改变与整个青春期中抑郁症状的增加有关.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 发展心理学 发展心理学
背景情况:
- 早期对环境污染物的暴露与青少年抑郁症有关.
- 连接污染和抑郁的神经生物学机制仍然不清楚.
研究的目的:
- 研究青春期早期污染负担与情绪调节期间大脑功能之间的关联.
- 检查污染相关的大脑变化如何与抑郁症状轨迹有关.
主要方法:
- 在145名青少年 (9-13岁) 的长度研究中,通过住所地址评估污染负担.
- 在隐性情绪调节任务期间的fMRI扫描.
- 在大约6年的三个时间点评估抑郁症状.
主要成果:
- 在负面情绪调节期间,更高的污染负担与增加的中间前额叶皮层激活和默认模式网络连接相关.
- 这种改变的大脑功能与随着时间的推移,抑郁症状的增加有关.
结论:
- 在高污染地区的青少年在负面情绪调节期间表现出改变的默认模式网络功能.
- 这种神经变化与青春期抑郁症状恶化有关.
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