牛乳粉补充作为抑郁症和物质使用障碍治疗的新视角:一个随机的安慰剂受控研究
Krzysztof Durkalec-Michalski1,2, Natalia Główka1, Tomasz Podgórski3
1Department of Sports Dietetics, Poznań University of Physical Education, Poznań, Poland.
Frontiers in psychiatry
|July 3, 2024
概括
牛乳粉 (BOV-COL) 补充剂在患有物质使用障碍 (SUD) 的患者中显示出作为抑郁症补充治疗的前景. 它改善了抑郁症得分,并比安慰剂更有效地减少了炎症标志物.
科学领域:
- 临床医学 临床医学
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 药物使用障碍 (SUD) 通常与抑郁症同时发生,使治疗复杂化.
- 炎症标志物和神经递质失衡与抑郁症有关.
- 对于SUD和抑郁症同时发生,需要新的治疗策略.
研究的目的:
- 评估牛乳粉 (BOV-COL) 作为SUD住院患者抑郁症的补充疗法.
- 评估BOV-COL对抑郁症症状严重性的影响.
- 为了研究血液炎症标志物和神经递质的变化.
主要方法:
- 随机,安慰剂控制,双盲,并行研究.
- 纳入了29名患有SUD和抑郁症的住院患者 (MMPI-2得分≥60).
- 参与者接受了BOV-COL (3200毫克/天) 或安慰剂3个月.
主要成果:
- 这两组都显示了贝克抑郁 inventory-II分数的降低.
- 汉密尔顿抑郁症评分表得分仅在BOV-COL组显著下降.
- BOV-COL组表现出多种炎症标志物的减少 (IL-1,IL-6,IL-10,IL-17,TNF-α) 和有利的白细胞子集变化.
- 没有观察到神经递质度的显著变化.
结论:
- 牛乳粉 (BOV-COL) 补充似乎是一个有前途的补充治疗抑郁症在患有物质使用障碍 (SUD) 的患者.
- 通过调节炎症通路,BOV-COL可能会发挥其益处.
- 需要进一步的研究来证实这些发现并阐明机制.
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