对于儿科固体瘤,CAR T细胞被重定向到B7-H3:当前状况和未来前景
Rebecca Epperly1, Stephen Gottschalk1, Christopher DeRenzo1
1Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.
EJC paediatric oncology
|July 3, 2024
概括
针对B7-H3的CAR T细胞疗法对儿科固体瘤有希望. 正在制定战略,以克服这些挑战,并提高这些难以治疗的癌症的治疗效率.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科瘤学 儿科瘤学
- 癌症治疗 癌症治疗
背景情况:
- 患有复发或耐药固体瘤的儿科患者的治疗选择有限.
- B7-H3 (CD276) 是一个有前途的目标,因为它在各种儿科固体瘤中的高表达和有限的正常组织表达.
研究的目的:
- 审查针对B7-H3-向的化学抗原受体 (CAR) 针对儿科固体瘤的T细胞疗法.
- 概述临床前发展和正在进行的临床试验.
- 确定和讨论克服CAR T细胞治疗固体瘤的挑战的策略.
主要方法:
- 对B7-H3-CAR T细胞发育的临床前数据的审查.
- 对正在进行的儿科临床试验的分析.
- 确定对实体瘤中CAR T细胞疗法的挑战和建议解决方案.
主要成果:
- B7-H3在儿科固体瘤的全谱中表达高,使其成为一个有吸引力的治疗点.
- 对B7-H3-CAR T细胞的临床前策略和积极的临床试验正在出现.
- 关键的挑战包括瘤透,微环境耐药性和T细胞持久性.
结论:
- B7-H3-CAR T细胞疗法代表了小儿固体瘤的新方法.
- 先进的CAR T细胞设计和组合疗法对于提高疗效至关重要.
- 需要进一步的研究和临床试验来优化这种治疗方式.
关键词:
B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3在CAR T细胞疗法中.化学抗原受体的化学抗原受体免疫治疗是一种免疫疗法.儿科癌症 儿科癌症固体瘤是一个固体瘤.更多相关视频
09:56A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
484
08:46A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
Published on: November 12, 2019
53.3K
相关概念视频
01:27Tumor Immunotherapy
509
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
509
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K