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吸烟,饮酒和脏清细胞癌之间的因果关系:孟德尔的随机化研究
Hongbin Cui1,2, Junji Du1,2, Hongbo Xue1,2
1Tianjin Medical University, Tianjin, China.
Frontiers in genetics
|July 3, 2024
概括
这项研究使用孟德尔随机化来调查吸烟,酒精和癌之间的因果关系. 结果表明,饮酒可能会降低细胞癌的风险,而吸烟增加了风险.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 观察性研究将烟草和酒精使用与细胞癌 (RCC) 风险联系起来.
- 这些生活方式因素与RCC之间的因果关系仍然不确定.
研究的目的:
- 为了确定吸烟和饮酒是否会对患细胞癌的风险产生因果影响.
- 使用门德尔随机化 (MR) 来评估这些暴露的遗传倾向.
主要方法:
- 进行了对两个样本的孟德尔随机化 (MR) 分析.
- 仪器变量包括单核酸多态 (SNPs) 对于吸烟开始,每日吸烟量,终身吸烟指数和每周饮酒量.
- 来自FinnGen联盟 (N=429,290) 的结果数据使用逆变量加权 (IVW) 方法进行分析,使用MR-Egger和MR-PRESSO进行变性评估.
主要成果:
- 基因预测的吸烟开始显示出与增加细胞癌风险的显著因果关系 (OR = 1.55,p = 0.03).
- 每日吸烟或终身吸烟指数对RCC风险没有发现显著的因果关系.
- 每周饮酒的遗传倾向与细胞癌的风险降低有关 (OR = 0.45,p = 0.007).
结论:
- 这项MR研究表明吸烟开始在增加细胞癌风险方面可能起因作用.
- 相反,基因预测的每周饮酒量似乎对细胞癌有保护作用.
- 需要进一步的研究来证实这些发现,并阐明潜在的机制.
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