饮食和的风险:孟德尔的随机化分析
Yanjiang Yang1, Biao Han2,3, Wenwen Yang4
1The People's Hospital of Qiandongnan Autonomous Prefecture, Kaili, Guizhou, China.
Frontiers in nutrition
|July 3, 2024
概括
饮食习惯会影响的风险. 每周饮酒可能会降低 inguinal hernia 的风险,而经常饮酒和不油性鱼类则会增加风险. 某些食物,如奶酪和干果,可能会降低腹的风险.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 遗传流行病学遗传流行病学
背景情况:
- 饮食和发生之间的联系仍然不太清楚.
- 调查特定的饮食成分对各种类型的影响对于公共卫生至关重要.
- 现有的研究缺乏对饮食因素和病因学的全面分析.
研究的目的:
- 研究各种饮食因素与患上 inguinal,和腹的风险之间的因果关系.
- 利用大规模的遗传和饮食数据集进行可靠的分析.
- 为了确定可能增加或减少风险的特定饮食成分.
主要方法:
- 利用英国生物银行获取饮食暴露数据 (酒精,鱼,水果,盐,奶酪等). ) 的情况.
- 雇佣了FinnGen生物库用于全基因组关联研究 (GWAS) 关于结局的数据.
- 使用孟德尔随机化方法 (加权中位数,MR-Egger,IVW) 进行因果推断,并进行异质性和异常值分析 (Cochran's Q,MR-PRESSO).
主要成果:
- 每周的酒精消费与 inguinal 的风险降低有关 (OR:0.614).
- 增加的酒精摄入频率与较高的腹腔风险相关 (OR: 1.309).
- 非油性鱼类的摄入增加了 inguinal 的风险 (OR: 2.945),而盐的摄入增加了带的风险 (OR: 1.841).
- 奶酪 (OR:0.434) 和干果 (OR:0.322) 的摄入量降低了腹腔的风险,而煮熟的蔬菜增加了风险 (OR:4.475).
结论:
- 特定的饮食因素,包括酒精,非油性鱼,盐,奶酪,干果和煮熟的蔬菜,与不同类型的有关.
- 研究结果强调了饮食在预防和管理中的潜在作用.
- 需要进一步的研究来阐明这些饮食与发育相关的机制.
关键词:
门德尔的随机化通过饮食摄入的摄入量切口椎间板裂 切口椎间板裂inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia inguinal hernia一个带.
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