循环中的矿物质和维生素与妊娠并发症的关联:孟德尔的随机化研究
Yuan Xie1, Jie Zhang2, Shuang Ni1
1Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in nutrition
|July 3, 2024
概括
更高的维生素E摄入量可能会降低自发流产 (SA) 的风险,而维生素B12可能与死产 (SB) 有关. 这些微量营养素的发现可以为预防妊娠并发症的策略提供信息.
科学领域:
- 营养流行病学 营养流行病学
- 生殖健康 生殖健康
- 遗传流行病学遗传流行病学
背景情况:
- 不一致的证据将微量营养素与怀孕并发症联系起来.
- 缺乏对这些关联的因果关系确认.
- 本研究使用孟德尔随机化研究因果关系.
研究的目的:
- 探索循环中的微量营养素与不良妊娠结果之间的因果关系.
- 提供关于怀孕期间有针对性的营养干预措施的证据.
主要方法:
- 采用了双样本的门德尔随机化 (MR) 分析.
- 使用全基因组关联研究 (GWAS) 的微量营养素和怀孕结果数据.
- 应用了逆方差加权 (IVW),加权中位数 (WM) 和MR-Egger方法,并进行了灵敏度分析和元分析以验证.
主要成果:
- 基因预测较高的维生素E水平与自发流产 (SA) 风险呈反向关联 (OR=0.993,p=0.005).
- 确定了对维生素B12的遗传倾向和死产 (SB) 之间的潜在积极因果关系 (IVW OR=0.974,p=0.018;WM OR=0.965,p=0.013).
- 对于其他分析的微量营养素和妊娠并发症,没有发现因果关系.
结论:
- 这项研究为维生素E和SA以及维生素B12和SB之间的关联提供了因果关系证据.
- 这些发现对于查和预防妊娠并发症至关重要.
- 结果可以指导临床实践和公共卫生政策,在怀孕期间提供个性化的营养支持.
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