在被诊断患有粘多糖糖症的患者中评估脏和唾液微生物分析
1Department of Pediatric and Preventive Dentistry, PSM College of Dental Sciences, Thrissur, Kerala, India.
概括
患有粘多糖症 (MPS) 的儿童表现出口腔细菌和酸性唾液的增加,导致牙损伤的发病率更高. 定期的牙科护理对于在MPS患者中管理这些口腔健康问题至关重要.
科学领域:
- 生物化学 生物化学
- 口腔生物学 口腔生物学
- 遗传学 遗传学 是一个
背景情况:
- 粘多糖症 (MPS) 是一组遗传性溶酶体储存障碍.
- MPS会导致多糖的积累,导致全身和口腔健康问题.
- 在MPS患者的口腔表现需要临床和放射性评估.
研究的目的:
- 为了评估患有MPS的儿童牙损伤的患病率.
- 评估MPS患者的唾液pH和微生物群的变化.
- 为了比较MPS患者和健康对照者之间的口腔健康参数.
主要方法:
- 一项涉及50名MPS儿童和50名健康儿童 (3-15岁) 的比较研究.
- 记录了唾液pH值和腐烂,缺失和填充牙 (DMFT) 指数.
- 唾液的微生物分析包括在各种亚格基质上培养,以计算殖民地形成单位数量.
主要成果:
- 在MPS患者中,总微生物负荷,Streptococcus viridans和Candida物种显著增加.
- 在MPS患者的初级牙和永久牙中,携带发生率显著更高.
- 在被诊断为MPS的儿童中,唾液pH值显著更为酸性.
结论:
- 患有MPS的患者的微生物负载较高,唾液酸性更高,因此,的发病率更高.
- 这些发现凸显了MPS患者牙损伤风险增加.
- 综合牙科评估,预防和治疗对于MPS患者的医疗保健至关重要.
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